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Aminouracil Mustard: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Aminouracil Mustard - General Information

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.

 

Pharmacology of Aminouracil Mustard

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

 

Additional information about Aminouracil Mustard

Aminouracil Mustard Indication: Used for its antineoplastic properties. Mechanism Of Action: After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Uracil mustard Synonyms: Not Available Drug Category: Antineoplastic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Uracil mustard: Aminouracil Mustard; Chlorethaminacil; Demethyldopan; Desmethyldopan; Haemanthamine; Nordopan; Uracil nitrogen mustard; Uracillost; Uracilmostaza; Uramustin; Uramustine; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: 5% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Aminouracil Mustard: Not Available Chemical IUPAC Name: 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione Chemical Formula: C8H11Cl2N3O2 Uracil mustard on Wikipedia: https://en.wikipedia.org/wiki/Uracil_mustard Organisms Affected: Humans and other mammals